SCIENTIFIC STUDIES PROVE THE EFFECTIVENESS OF LIGHT/PEROXIDE TREATMENT

Light Augments Tooth Whitening With Peroxide

JADA 2003;134(2):167-75.
Background
The authors tested the adjunctive use of light with a 15 percent peroxide gel as a single-visit, in-office tooth whitening system.
Methods
Subjects (N=87) with stained (>shade D4, Vita Zahnfabrik, Bad Säckingen, Germany) anterior teeth were randomly assigned to test (peroxide and light), peroxide control (peroxide gel) or light control (placebo gel and light) groups and were treated for one hour. The researchers evaluated tooth shade, color and subject response at baseline and post treatment and at three and six months post treatment.
Results
The initial shade unit reduction of combined light and peroxide treatment (8.4) was greatest compared with that of peroxide alone (5.9) and of light alone (4.9). Approximately 88 percent of these effects persisted for six months. Lightness was increased and yellowness decreased to a significantly greater extent in the test group than in either control. These findings were corroborated by subject evaluation. One week after treatment, moderate to greatly increased tooth sensitivity occurred in 20 percent of test subjects, 21.7 percent of peroxide control subjects and none of the light control subjects. Neither tooth sensitivity nor gingival redness was present at the three and six month visits.
Conclusions
Peroxide and light treatment significantly lightened the color of teeth to a greater extent than did peroxide or light alone, with a low and transient incidence of tooth sensitivity.
Clinical Implications
Light can increase the cosmetic teeth whitening effect of peroxide, thereby increasing the effectiveness of tooth-whitening procedures.
Tavares M, Newman , Smith V et al. Light augments tooth whitening with peroxide.
JADA 2003;134(2):167-75. Copyright © 2003 American Dental Association. All rights reserved. Table of Contents Page on the ADA.org Web site and follow the instructions to view the article in the February 2003 archive section. Please note that ADA members and JADA paid subscribers have full access free of charge, while all other visitors must pay an access fee per Journal article.

Blue light fights gum disease culprits, Forsyth scientists find

Main Category: Dentistry News
Article Date: 01 Apr 2005 - 0:00 PDT


Boston--Scientists at The Forsyth Institute have found that blue light can be used to selectively suppress certain bacteria commonly associated with destructive gum disease.

The research, published in the April Journal of Antimicrobial Agents and Chemotherapy, suggests that light in the blue region of the visible spectrum might be useful in preventing, controlling or treating periodontitis -- an oral infection that can lead to loss of bone and teeth.

"Some of the key bacterial pathogens associated with periodontitis produce and accumulate compounds that are sensitive to light," said Nikos Soukos, DDS PhD, Director of the Forsyth Laboratory of Applied Molecular Photomedicine and the principal investigator. "We found that, when exposed to particular wavelengths of light, a percentage of those pathogens was eradicated within seconds."

Another important finding was that when the proportion of such pathogens was reduced, the proportion of other, potentially helpful, bacteria increased. "This suggests that it might one day be feasible to use light to restore a healthy bacterial balance in the mouth," Soukos said.

The current research stemmed from an observation by Max Goodson DDS, PhD, Director of Clinical Research at Forsyth, that the blue light used in a tooth whitening procedure appeared to decrease inflammation of the gums.

The team is currently developing a hand-held, light-based device that might, one day, be used by consumers to help combat periodontal disease.

If proved effective in clinical trials Goodson said, "Technology employing blue light to improve oral ecology could be the most important advance in maintaining periodontal health since the invention of the toothbrush."

Background
Previous Forsyth research had shown that as many as 700 different types of oral bacteria may be found in dental plaque that accumulates on teeth. While some bacteria appear to be benign or even helpful, others may invade and destroy gum tissue and bone -- leading to loss of teeth, and, possibly, to infection elsewhere in the body.

Among the more destructive bacteria are the so-called "black-pigmented bacteria" (BPB) which have been implicated as pathogens associated with periodontitis. Such bacteria accumulate black pigment consisting mainly of organic compounds called porphyrins. Some porphyrins are photosensitive, and, when activated by visible light, induce a photodynamic reaction that kills the microorganism within seconds.

In embarking on their research, Soukos and Goodson knew that other researchers had used lasers to deliver red or green light, which partially inactivated certain oral bacteria. The Forsyth team also knew, from published reports, that porphyrins absorb blue light more readily than light that is red or green.

The team employed a halogen lamp source commonly used for tooth whitening to shine broadband light comprised mainly of blue and a small percentage of green light (wavelengths ranged from 380 to 520 nanometers) on pure cultures of BPB and on dental plaque samples obtained from individuals with chronic periodontitis.

They found that the light rapidly killed BPB in pure cultures and that it selectively eliminated BPB in plaque samples containing 500-600 different bacteria. They also found that certain species were more readily inactivated by the light than others and that varying the intensity and exposure time had different impacts on different species.

The researchers conclude that intraoral light exposure can selectively reduce pathogens in dental plaque.

If proved effective in clinical studies, the findings could lead to new methods for preventing or controlling periodontal disease. Such methods would be rapid, non-invasive, and nontoxic, Soukos said.